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Tomoya Nakamachi Selected Research

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)

4/2020Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Is Responsible for Food Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice.
7/2019Effects of PACAP on Dry Eye Symptoms, and Possible Use for Therapeutic Application.
1/2019Expression Patterns of PACAP and PAC1R Genes and Anorexigenic Action of PACAP1 and PACAP2 in Zebrafish.
1/2018[Novel tear secretion system - the effect and the mechanism of PACAP on tear secretion].
9/2016Pleiotropic and retinoprotective functions of PACAP.
6/2016Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Is Involved in Adult Mouse Hippocampal Neurogenesis After Stroke.
1/2016Pituitary adenylate cyclase-activating polypeptide enhances saliva secretion via direct binding to PACAP receptors of major salivary glands in mice.
1/2016PACAP suppresses dry eye signs by stimulating tear secretion.
10/2015PACAP as a neuroprotective factor in ischemic neuronal injuries.
3/2015Two-color Dye-swap DNA Microarray approach toward confident gene expression profiling in PMCAO mouse model for ischemia-related and PACAP38-influenced genes.
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Tomoya Nakamachi Research Topics

Disease

20Ischemia
06/2016 - 04/2004
9Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
03/2015 - 11/2004
8Body Weight (Weight, Body)
10/2022 - 09/2005
7Brain Ischemia (Cerebral Ischemia)
01/2013 - 04/2004
5Stroke (Strokes)
06/2016 - 03/2006
5Brain Injuries (Brain Injury)
06/2016 - 01/2011
5Wounds and Injuries (Trauma)
10/2015 - 04/2004
4Infarction (Infarctions)
01/2015 - 05/2006
4Traumatic Brain Injuries (Traumatic Brain Injury)
02/2011 - 11/2006
3Dry Eye Syndromes (Dry Eye Syndrome)
07/2019 - 01/2016
3Inflammation (Inflammations)
01/2018 - 02/2015
3Spinal Cord Injuries (Spinal Cord Injury)
02/2015 - 11/2012
2Ischemic Stroke
03/2015 - 11/2006
2Ganglion Cysts (Ganglion)
10/2013 - 11/2008
2Hypoxia (Hypoxemia)
02/2013 - 01/2012
2Contusions
11/2012 - 07/2010
2Optic Nerve Injuries
01/2012 - 11/2008
1Mental Disorders (Mental Disorder)
11/2021
1Psychotic Disorders (Schizoaffective Disorder)
11/2021
1Pathologic Processes
12/2020
1Metabolic Syndrome (Dysmetabolic Syndrome X)
12/2020
1Infections
04/2020
1Bacterial Infections (Bacterial Infection)
01/2020
1Eye Injuries (Eye Injury)
09/2016
1Xerostomia
01/2016
1Pain (Aches)
02/2015
1Hyperalgesia
02/2015
1Neuralgia (Stump Neuralgia)
02/2015
1Astrocytoma (Pilocytic Astrocytoma)
11/2014
1Atherosclerosis
11/2014
1Abdominal Aortic Aneurysm
11/2014
1Sudden Infant Death (SID)
02/2013
1Perinatal Death
02/2013
1Stab Wounds (Stab Wound)
01/2013
1Alzheimer Disease (Alzheimer's Disease)
08/2012
1Brain Hypoxia (Cerebral Hypoxia)
03/2012
1Cerebral Infarction
03/2012
1Cardiovascular Diseases (Cardiovascular Disease)
06/2011
1Insulin Resistance
06/2011
1Gliosis
01/2011
1Glaucoma
01/2011
1Cardiomyopathies (Cardiomyopathy)
06/2010

Drug/Important Bio-Agent (IBA)

35Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA
04/2020 - 04/2004
7Pituitary Adenylate Cyclase-Activating Polypeptide ReceptorsIBA
04/2020 - 04/2004
6Neuroprotective AgentsIBA
10/2015 - 11/2006
6NeuropeptidesIBA
03/2015 - 02/2011
5DNA (Deoxyribonucleic Acid)IBA
03/2015 - 08/2007
5OrexinsIBA
07/2014 - 03/2005
4Peptides (Polypeptides)IBA
01/2020 - 02/2009
4Proteins (Proteins, Gene)FDA Link
09/2014 - 11/2004
4Interleukin-6 (Interleukin 6)IBA
11/2012 - 04/2004
3Dihydrotachysterol (AT 10)IBA
10/2022 - 01/2017
3Saline SolutionIBA
01/2015 - 11/2012
3Messenger RNA (mRNA)IBA
01/2013 - 11/2004
3Cytochromes c (Cytochrome c)IBA
08/2007 - 05/2006
2NADPH Oxidases (NAD(P)H oxidase)IBA
11/2014 - 07/2010
2Superoxides (Superoxide)IBA
11/2014 - 07/2010
2Orexin ReceptorsIBA
07/2014 - 02/2011
2Retinaldehyde (Retinal)IBA
01/2012 - 01/2011
2EdaravoneIBA
02/2007 - 11/2006
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2006 - 09/2004
1tofisopamIBA
10/2022
1GABA-A Receptors (GABA(A) Receptor)IBA
10/2022
1EnzymesIBA
11/2021
1SugarsIBA
11/2021
1Glucose (Dextrose)FDA LinkGeneric
11/2021
1Sucrose (Saccharose)IBA
11/2021
1Melanocyte-Stimulating Hormones (MSH)IBA
11/2021
1urotensin IIIBA
12/2020
1Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA
01/2020
1Transforming Growth Factors (Transforming Growth Factor)IBA
01/2020
1LipopolysaccharidesIBA
01/2020
1MucinsIBA
01/2018
1Bromodeoxyuridine (BrdU)IBA
06/2016
1Artificial SalivaIBA
01/2016
1Coloring Agents (Dyes)IBA
03/2015
1InterferonsIBA
02/2015
1CarrageenanIBA
02/2015
1Nonesterified Fatty Acids (NEFA)IBA
02/2015
1Analgesics (Analgesic Drugs)IBA
02/2015
1GW9508IBA
02/2015
1Sodium ChlorideFDA LinkGeneric
01/2015
1NADP (NADPH)IBA
11/2014
1Apolipoproteins E (ApoE)IBA
11/2014
1Oxidoreductases (Dehydrogenase)IBA
11/2014
1ApolipoproteinsIBA
11/2014
1Angiotensin IIIBA
11/2014
1N-Methylaspartate (NMDA)IBA
10/2013
1Glial Fibrillary Acidic ProteinIBA
01/2013
1salicylhydroxamic acid (SHAM)IBA
11/2012
1Oxygen (Dioxygen)IBA
03/2012
1Sirtuin 1IBA
06/2011
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2011
1Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
07/2010
1Nitric Oxide (Nitrogen Monoxide)FDA Link
07/2010
1Peroxynitrous Acid (Peroxynitrite)IBA
07/2010

Therapy/Procedure

2Lasers (Laser)
11/2012 - 01/2010
1Spinal Injections
02/2015
1Injections
01/2015
1Intravitreal Injections
10/2013